Papasolum belongs to the category of antispasmodic drugs. Papazol, in addition to the antispasmodic effect, also has an antihypertensive and arteriodilatory effect. International name: Papaverine + Bendazol (Papaverine + Bendazol). Composition and form of release Papazol is a combined preparation. Active ingredients: papaverine and bendazole (0.03 g each). Available in the form of white tablets, 10 pcs. in one package. Pharmacological action Bendazol in Papazol is a myotropic antispasmodic agent. It affects the body as follows: has a hypotensive effect; has a vasodilating effect; stimulates the functions of the spinal cord; moderately stimulates immune activity. Papaverine is also an antispasmodic with an antihypertensive effect. According to the instructions for Papazol, papaverine: causes inhibition of PDE; promotes the accumulation of cAMP in the cell; reduces the content of Ca2 +; helps to reduce the tone and relaxation of the smooth muscles of the stomach, intestines, as well as the organs of the genitourinary and respiratory systems; helps to reduce tone and relax smooth muscles and blood vessels. A large dose of Papazol suppresses the excitability of the heart muscle and slows down intracardiac conduction. The drug has practically no effect on the central nervous system. Large doses can cause sedation. The therapeutic effect of taking Papazol is: in the expansion of the vessels of the heart and brain; in lowering blood pressure; in relaxing the smooth muscles of the stomach and intestines. Indications The use of Papazol may be necessary in the following cases: with labile arterial hypertension; if there is a spasm of peripheral arteries and / or cerebral vessels; with spasms of smooth muscles of internal organs (including diseases such as stomach ulcers, duodenal ulcers, pyloric spasms, intestinal colic, cholecystitis, spastic colitis); if there are residual manifestations of poliomyelitis; with peripheral paralysis of the facial nerve. Contraindications to the use of Papazol The drug Papazol is not prescribed in the following cases: with increased sensitivity to its components; if AV conduction disturbances are observed; with epileptic syndrome; with broncho-obstructive syndrome; children under one year old. With caution, Papazol can be prescribed: with reduced intestinal motility, with craniocerebral trauma, hepatic and renal failure, hypothyroidism, adrenal insufficiency, prostatic hypertrophy, during pregnancy and lactation. See also: 8 effective folk remedies for combating peptic ulcer disease Fighting hypertension: 5 best folk remedies 8 unusual symptoms of severe ailments Method and features of administration Adult patients drink one Papazol tablet 2 or 3 times a day two hours before meals or two hours after him. The duration of the course of treatment depends on the individual characteristics of the patient and the nature of the course of the disease. As a rule, reviews of Papazol confirm this, it is from 2 to 4 weeks (in adults). The dosage of the drug and the duration of the course of treatment in children are determined by the attending physician. The safety of Papazol for pregnant and lactating women has not been established. The indications for Papazol are determined by the attending physician. During the period of drug treatment, the intake of alcoholic beverages should be excluded. Adverse reactions from taking Papazol According to medical reviews, Papazol can cause: allergic reactions; nausea; constipation; increased sweating; dizziness; AV block; arrhythmia; decrease in myocardial contractility. Interaction with other drugs Simultaneous administration of Papazol with antispasmodic drugs, sedatives, diuretics, tricyclic antidepressants, novocainamide, reserpine, quinidine sulfate can enhance the manifestation of the hypotensive effect. Papazol helps to reduce the effect on smooth muscles of anticholinesterase drugs, reduces the antiparkinsonian effect of levodopa. Concomitant use with nitrofurantoin may contribute to the development of hepatitis. Adsorbents, preparations with astringent and enveloping effect, reduce the absorption of Papazol.
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