What is the drug Polygot


The information about Polygot contained on this website is for information purposes only. The information contained herein should not be used by patients to make independent decisions about the use of the medicines presented and should not be used as a substitute for personal medical advice.

What is the drug Polygot

Polygot is a combined antimigraine drug. The effect of Polygot is associated with the vasoconstrictor effect of ergotamine and improvement of cerebral function under the influence of caffeine. Ergotamine causes a vasoconstrictor effect. Caffeine accelerates absorption of ergotamine and enhances the effect of ergot alkaloids in treatment of migraine. Caffeine also causes stimulation of the central nervous system, mainly in the cerebral cortex, respiratory and vasomotor centers. It increases mental and physical performance, reduces sleepiness and fatigue. Caffeine has a pronounced cardiotonic effect: it increases strength and heart rate, increases blood pressure in hypotension.

Polygot is used when:

  • vasoparalytic form of migraine;
  • arterial hypotension;
  • as a means of lowering intracranial pressure in vascular, traumatic and infectious lesions of the central nervous system.

Side effects

What is the drug Polygot

Nervous system disorders: agitation, anxiety, tremor, restlessness, headache, dizziness, convulsions, paresthesia in the extremities, increased reflexes, tachypnoea, insomnia; in abrupt withdrawal – central nervous system inhibition, increased fatigue, sleepiness.
Cardiovascular system: palpitations, tachycardia, cardialgia, hypertension (increased blood pressure).
Digestive system: nausea, vomiting, diarrhea.
Allergic reactions: edema, skin itching.
Other: with long-term use – weakness in the legs, myalgia, Lerish syndrome (cyanosis, lack of pulse in the lower extremities, pain, distal sensitivity disorders).

Dosage and administration

Orally, 1-2 tablets 2 times a day during a headache attack, then 1 tablet 2-3 times a day for several days (up to 1 month). The maximum single dose is 2 tablets, the daily dose is 4 tablets.
It is not recommended to use Polygot for a long time (to avoid ergotism phenomena): after 7 days of use, a break is made (for 3-4 days) in cases that require longer treatment.


Symptoms: anxiety, nervousness, irritability, insomnia, flushed face, increased diuresis, nausea, vomiting, muscle twitching, tachycardia or arrhythmia, psychomotor agitation, tremor, hypertonia, confusion, hyperreflexia, numbness in fingers and toes, epileptic seizures.
Treatment: withdrawal of Cofetamine; gastric lavage, prescription of activated charcoal, if necessary – symptomatic therapy; beta-adrenoblockers (propranolol) prevent cardiotoxic effect and normalize blood pressure.


A physician should be consulted before using Polygote. Care should be taken to avoid an overdose of Polygote. Prolonged use of Polygote is not recommended.